Another important miRNA, miR-199a-3p, is downregulated in virtually all HCCs,17 and it is involved in the control of several cancer-associated genes, such as mechanistic target of rapamycin (mTOR), the hepatocyte growth factor receptor MET, the kinase p21-activated kinase 4 (PAK4), and the Notch regulator YAP1.18, 19, 20. The gene discussed is PAK4; the disease is cancer.