We did not detect LPS in serum of whipworm-infected IL-10 signalling-deficient mice (with values below the sensitivity threshold of the assay), suggesting that either the pathobionts mediating the disease are Gram-positive and therefore, other microbial products, such as LTA and peptidoglycan, may be the cause of systemic immunopathology or that opportunistic pathogens and their products were confined to the liver where they cause liver failure and disease. Here, IL10 is linked to liver failure.