Similarly, no transfer of microbiota was observed in IL-10 mutant mice co-housed with Il10-/-Nlrp6-/- mice harbouring an expanded population of the pathobiont Akkermansia muciniphila [43]. Together, these results suggest that deficiency in IL-10 signalling alone is insufficient to trigger dysbiosis; whipworm infection is required to reach this disbalanced state. The gene discussed is NLRP6; the disease is trichuriasis.