IL10 and Sepsis: While IL-10 signalling is critical in controlling microbiota homeostasis and gut and liver immunopathology during whipworm infections, our data indicated that IL-22 is dispensable in the responses to T. muris. Interestingly, in our facility IL-22Rα-deficient mice infected with C. rodentium presented similar dysbiosis and sepsis-like pathology (caused by E. faecalis) to the one observed in whipworm-infected IL-10 signalling-deficient mice [32].