To further investigate which cells of haematopoietic origin are mediating the regulatory functions of IL-10 during whipworm infections, we infected RAG1-deficient mice, which lack the adaptive immune compartment (T and B cells), with a high dose of T. muris. These mice developed a chronic infection with no symptoms of immunopathology (Fig 10A and 10C). The gene discussed is RAG1; the disease is trichuriasis.