Conversely, reconstitution of irradiated IL-10Rα and IL-10Rβ mutant mice with WT donor bone marrow protected them from the unsustainable pathology caused by whipworm infection (Figs 9C and 9D and S13C and S13D). These results suggest that the main target cells responding to IL-10 are of haematopoietic origin. This evidence concerns the gene IL10RA and trichuriasis.