For example, SENP3 deSUMOylates the HIF1α coactivator P300 to increase angiogenesis under hypoxia [42], deSUMOylates promyelocytic leukemia in response to mild oxidative stress[18], and de-SUMOylating FOXC2 to facilitate epithelial-mesenchymal transition in gastric cancer cells [17]. The gene discussed is FOXC2; the disease is acute promyelocytic leukemia.