For the converse experiment, we generated isogenic PD astrocytes lacking the LRRK2 G2019S mutation by CRISPR/Cas9-mediated gene editing of PD iPSCs (iPSC line PD SP13, from here on referred to as PD iso), and fully characterized these cells (Figures S5A–S5E). This evidence concerns the gene LRRK2 and Parkinson disease.