LRRK2 and Parkinson disease: Moreover, co-culturing gene-corrected astrocytes with Ctrl vmDAns for 4 weeks prevented the accumulation of α-syn and decrease in neuron survival observed when Ctrl vmDAns were co-cultured with PD astrocytes (Figures S5H–S5J), further supporting that the expression of mutant LRRK2 in astrocytes is pathogenic to Ctrl vmDAns.