LRRK2 and Parkinson disease: Specifically, astrocyte cultures were successfully established from iPSC lines from three PD patients carrying the G2019S mutation in the LRRK2 gene (PD SP06, PD SP12, and PD SP13) and two healthy age-matched controls (Ctrl SP09 and Ctrl SP17) (see Table 1 and Tables S1 and S2 for a summary of the iPSC lines used, and Experimental Procedures for details on their origin).