Nugent-BV has repeatedly been associated with genital inflammation; in particular, proinflammatory cytokines are typically upregulated, whereas chemokines show no association, are upregulated (i.e., IL-8), or downregulated.10,14–16 This cytokine–chemokine distinction is likely due to the observation that BV is microbiologically multifaceted, and specific combinations of bacterial species may result in different host responses.28 The host response to the same bacterial communities could also vary between individuals, even though no studies have evaluated this specific question. This evidence concerns the gene CXCL8 and bacterial vaginosis.