HGF and cancer: It seems that the mechanisms that underlie the prometastatic activity of CS‐E may involve effects on the cell motility stimulators such as VEGF and HGF 189, 190, the promotion of circulating cancer cell survival and extravasation via the interaction with P selectin 191, support of tissue colonization by binding to local receptors such as RAGE 46, and the stimulation of activation and/or activity of enzymes responsible for ECM degradation such as MMP‐7 192, which is implicated in the disruption of cell‐ECM contacts 193.