It has been demonstrated that TIPE2 protein expression is very weak in rectum and is not detected or weakly expressed in most human carcinoma cell lines.41, 42 Another study has shown that TIPE2 expression is higher in colon cancer tissues compared to normal controls and it is related with lymph node metastasis and Dukes stage of colon cancer.43 Our results indicated that TIPE2 expression was higher in rectal adenocarcinoma tissues compared to adjacent nontumour tissues. This evidence concerns the gene TIPE2 and malignant colon neoplasm.