TIPE2 and carcinoma of esophagus: Wnt/β‐Catenin pathway regulates the expression of many genes involved in apoptosis and GSK‐3β plays a key role in Wnt/β‐Catenin signalling pathway.31, 32 Another study has shown that TIPE2 could suppress progression and tumourigenesis of esophageal carcinoma via inhibition of the Wnt/β‐catenin pathway.19 Similarly, our results indicated that the expression levels of Wnt3a, p‐β‐Catenin, and p‐Gsk‐3β in the TIPE2 group were lower than those in the Mock group.