More recently, it has been reported that Ras/MAPK signalling pathway is responsible for activation of EMT, and is associated with tumourigenesis.24, 47, 48 Suppression of Ras signalling by Rnd1 inhibited the following signalling cascades and consequently deregulated the activation of EMT.49 We checked the expression profiles of Ras genes (H‐Ras, K‐Ras, N‐Ras) in Tn‐positive vs Tn‐negative CRC cells, and found an increased expression of H‐Ras in cancer cells expressing Tn antigen, whereas the changes of K‐Ras or N‐Ras were not different. This evidence concerns the gene RND1 and colorectal carcinoma.