FH and coronary artery disorder: According to the guideline, the LDL‐C levels of adult FH patients should be controlled <2.5 mmol/L; if the patients were combined with CHD or diabetes, the LDL‐C level should be controlled <1.8 mmol/L.28 However, these FH mutation carriers are usually undertreated and have LDL‐C levels above the goal.