However the Schwann cell lesions arise from endoneurial layers and perineurioma arise from perineurial layer which made the term pseudo-onion bulb lesion more suitable and acceptable for the perineuriomas [4, 8] The immunohistochemical staining can help to distinguish between perineurioma and Schwann cell lesion as the first is positive for epithelial membrane antigen (EMA) and negative for (s-100) and the Schwann cell lesions demonstrate the opposite pattern [4]. Here, MUC1 is linked to perineurioma.