TGFB1 and keloid: This study also reported that that the longer the incubation time, the fewer keloid collagen deposition, but the keloid collagen deposition with tagitinin C treatment was fewer than treatment with mitomycin C. The collagen synthesis process began when the fibroblast got a stimulus from TGF-β that was bound to TGF-β receptors on the fibroblasts membrane.