Research on Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), that is a compound of sesquiterpene lactones, is known to inhibit the keloid fibroblasts proliferation, inhibit TGF-β1, and inhibit collagen synthesis of keloid through the NF-κB [18]. The gene discussed is NFKB1; the disease is keloid.