The best examples of the success of this screening method include the identification of the role of BCR and ABL as lethal hits in chronic myelogenous leukemia (CML) cell line KBM7, KRAS and PIK3CA and as lethal hits in colorectal cancer cell lines DLD-1 and HCT116 [68, 76]. This evidence concerns the gene PIK3CA and chronic myelogenous leukemia, BCR-ABL1 positive.