And genetic polymorphisms in these two genes were reported to associate with BC susceptibility, including the extensively studied SNPs such as rs2228480, rs3798577, rs2077647, rs2234693 in ESR1 and rs4986938, rs1256049 in ESR2 as well as less common SNPs such as rs3020314, rs1514348, rs1062577, rs1271572, rs1256054 and rs2987983 [5–8, 16–19]. The gene discussed is ESR2; the disease is breast cancer.