At last, the most common mutation in T-ALL was the Notch1 gene mutation and the deletion of chromosome 9/CDKN2A [43–45] Activation of Notch1 and inactivation of Notch1 negative regulator FBXW7 were found in 60% of T-ALL cases [46]. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.