AKT1 and acute lymphoblastic leukemia: The runaway of the PI3K/AKT/mTOR signaling pathway in a series of leukemias, including T-ALL, had led to the development of cancer [34–36] A study using zebrafish as a living model had demonstrated that the AKT pathway played a key role in the expansion of the leukemia cell pool and eventually led to hematologic recurrence [40].