Furthermore, overexpression of ClC-3 was significantly related to poor survival in cervical carcinoma, indicating it may be a latent predictor of cervical carcinoma prognosis; (iii) In vitro, ClC-3 was highly expressed in both SiHa and HeLa cell lines but it was expressed weakly in C-33A and H8 cell lines. The gene discussed is CLCN3; the disease is cervical carcinoma.