ANO1 and cervical carcinoma: Interestingly, researches have shown that Cl− currents activated by volume-sensitive chloride channels may play a crucial role leading to regulatory volume decrease (RVD) in human cervical cancer [28], Ano1 is a Ca2+ activated Cl(−) channel that produces Ca2+ activated Cl(−) currents and is related to the human papilloma virus (HPV) infection and cancer [29].