CLCN3 and central nervous system cancer: Using ShClC-3 adenovirus, the ClC-3 expression was downregulated, which can significantly reduce glioma cell volume-regulated chloride currents, reduce MMP-9 and MMP-3 expression by inhibiting the transcriptional activity of Nuclear Factor-kappa B (NF-kappa B), and reduce the migration and invasion ability of glioma cells [9].