Immunohistochemical analysis of CXCR4 expression was in line with previous studies showing the association between subcellular localisation and advanced and PD tumours,23–25 suggesting a possible involvement of CXCR4 in the intracellular signalling of NET cells as a functional nuclear importable receptor, which requires further investigation at the molecular level. Here, CXCR4 is linked to neoplasm.