We further bridged the Atp8b1G308V/G308V mice-based hyperoxia fibrosis model and human IPF pathology by revealing that IPF lungs display aberrant arrangement of CCSP-positive club cells in hyperplastic bronchiolar epithelium as well as increased claudin-10 expression in the lung. This evidence concerns the gene SCGB1A1 and idiopathic pulmonary fibrosis.