Therefore, it should be noted that despite a major impact of the APOE genotypes on the associations of other SNPs inside the chromosome 19q13 region with AD, this result would not automatically imply that the APOE SNPs (i.e., rs429358 and rs7412) are the only contributors to AD pathogenesis because APOE-adjusted models highlighted the statistical correlations rather than biological (i.e., genetic) linkage. This evidence concerns the gene APOE and Alzheimer disease.