IRAK3 and Alzheimer disease: SNPs with p < 5E–06 were present only in 1-Mb upstream/downstream regions of ATG10 (significant in brain-specific TWA analyses) in our GWA analyses of females, although several AD-associated SNPs with p < 5E–06 were reported in regions around TRA2A [64], IRAK3 [77], and ESPN [78].