CDH4 and Alzheimer disease: Among the closest genes to newly detected SNPs outside the chromosome 19q13 region, BIN1, FRMD4A, and CDH4 that were significant under plan 3 were previously associated with AD with p < 5E–06 (rs744373 with p = 2.60E–14 [66], rs7921545 with p = 5.40E–07 [67], and rs4925189 with p = 6.30E–07 [68], respectively).