However, the tumor suppressor function of piR-36,712 cannot be observed in T47D (luminal A), BT-474 (luminal B) and MDA-MB-231 (Triple negative breast cancer, TNBC) cells, which with the mutant P53 (Additional file 2: Figure S6A and S6C-S6G). The gene discussed is TP53; the disease is triple-negative breast carcinoma.