We also tested the effects of piR-36,712 on chemotherapy response in other subtypes of breast cancer cells, and found that the synergistically anticancer effects of piR-36,712 were reproduced in HCC1428 (wild type P53), but not in T47D, BT-474 and MDA-MB-231 cells (mutant P53) (Additional file 2: Figure S8A-S8H). The gene discussed is TP53; the disease is breast cancer.