HGSC is the most aggressive and common ovarian carcinoma that is believed to be closely associated with a TP53 mutation (type II carcinoma), whereas LGSC, as well as the other major ovarian cancer histological types, is one of the indolent ovarian malignancies that develops from the benign and/or borderline counterparts through multi-step carcinogenesis (type I carcinoma) [8]. The gene discussed is TP53; the disease is ovarian cancer.