In our immunohistochemical analyses, the cancer cells showed diffuse positive staining for p53 (clone: DO-7; Fig. 2i); block positive for p16 (Fig. 2j); partial positive for WT1 (Fig. 2k), ER, PgR (Fig. 2l), CDX2 and PAX8; and negative for p40, p63, GATA3, Napsin A and vimentin (data not shown). This evidence concerns the gene PAX8 and cancer.