There was no difference in the EGF repeat in which the mutation occurred between cases with and without encephalopathy (χ2, P=0.388) and in the proportion who had a mutation in EGFR repeat 1 to 6 versus 7 to 34 (encephalopathy 33 v 2 versus nonencephalopathy 256 v 49, χ2P=0.170). The gene discussed is EGF; the disease is Encephalopathy.