Among these genes, multiple studies confirmed PAX1 methylation as the most highly correlated with CIN progression and cervical carcinogenesis (Chang et al., 2014; Chao et al., 2013; Chen et al., 2016; Huang et al., 2010; Kan et al., 2014; Lai et al., 2010, 2014; Luan et al., 2017; Tian et al., 2017; Xu et al., 2015). The gene discussed is PAX1; the disease is cervical squamous intraepithelial neoplasia.