PRKAA2 and neoplasm: Numerous studies have shown the total effect of AMPKα1 or a2 deletion on types of mouse models, however, there is a limited study to show whether AMPKα1 and a2 play different roles in the same disease conditions although they seem to be activated by the same stimuli.50 Our previous results showed that AMPKα2 deficiency exacerbates the energy deprivation in AMPKα2−/− tumour‐bearing liver.17 And we also reported that the glucose starvation in tumours is related with the tumour size and location.