PRKAA2 and neoplasm: And a glucose gradient was observed in large tumour, which implied a glucose competition between the tumour and liver remnant.31 Furthermore, AMPK is activated by energy stress.37 It was not surprising that we observed the AMPK activation was higher in the tumour‐bearing liver of AMPKα2−/− mice, although the deletion of AMPKα2 resulted in decreased total AMPKα and no significant AMPKα1 compensation (Figure 5B).