PRKAA2 and neoplasm: The insufficient clearance of dead cells by phagocytes can lead to pathological inflammation,14 which further promote the development of tumour.15, 16 Our previous study showed that hepatocyte enriches AMPKα2 and liver metastasis results in glucose deprivation and necrosis of liver hepatocytes.17 AMPKα2 deficiency significantly aggravated the glucose deprivation and necrosis of hepatocytes via increased ROS production.