Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Nat Genet Nat Genet 2006 2006 38 38 441 441 446 446 16550169 16550169. The gene discussed is FLG; the disease is atopic eczema.