22 Domchek Domchek SM SM Friebel Friebel TM TM Singer Singer CF CF Evans Evans DG DG Lynch Lynch HT HT Isaacs Isaacs C C Garber Garber JE JE Neuhausen Neuhausen SL SL Matloff Matloff E E Eeles Eeles R R et al et al Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality JAMA JAMA 2010 2010 304 304 967 967 975 975 20810374 20810374. This evidence concerns the gene BRCA2 and cancer.