Subsequently, Friedrichs et al. pointed out the following differing features of a small bowel tumor in a 41-year-old patient: mixed alveolar and solid histological architecture, osteoclast-like giant cells present, coexpression of S-100 and vimentin, complete lack of HMB-45, melan-A, SMA, KIT receptor, desmin, CD-34 expression, and harbouring the following translocation: t(12;22)(q13;q12) [17]. Here, PMEL is linked to small intestine neoplasm.