We investigated whether obesity impacts SRSF2 and MBD2_v2 by inoculating a DIO mouse model with tumor‐forming TNBC cell lines, and in agreement with our hypothesis, SRSF2 and MBD2_v2 expression levels were significantly upregulated in tumors harvested from DIO mice displaying increased tumor formation rates. Here, SRSF2 is linked to obesity due to melanocortin 4 receptor deficiency.