Conversely, lifestyle factors contributing to systemic inflammation independent of obesity such as sleep deprivation and psychosocial stress are also more prominent in African Americans (Brody et al., 2015; Carroll et al., 2009; Curtis et al., 2017; Vgontzas et al., 1999), and inflammation in nonobese patients may influence the SRSF2‐MBD2_v2 axis and be a confounding variable for the association between obesity and MBD2_v2 expression in tumors from African American women. The gene discussed is SRSF2; the disease is obesity due to melanocortin 4 receptor deficiency.