Although the exact components within neuronal CM which are responsible for the inhibition of glioma CA11 expression are unclear, we found that this inhibitory effect of CM is mediated through the Akt signaling pathway as co‐treatment of glioma cells with CM, and inhibitors for Akt signaling (1 μm Perifosine or 1 μm MK‐2206) for 48 h blocked the inhibitory effect (Fig. 2F). This evidence concerns the gene AKT1 and glioma.