This effect is dependent on G protein–coupled receptor 41 (GPR41, also called free fatty acid receptor 3 or FFAR3), but not GPR43 (also called free fatty acid receptor 2 or FFAR2).55 DCs can also exert roles in adoptive T‐cell therapy (ACT) in cancer (Figure 1E), and the composition of the gut microbiome or treatment with antibiotics could lead to an increase in CD8α+ DCs, and consequent IL‐12 release that sustains the anti‐tumor ACT.63 The gene discussed is FFAR3; the disease is cancer.