They significantly eliminated liver fibrosis by down‐regulating hyaluronic acid and reducing the release of fibrotic factors such as α‐SMA, collagen and TIMP‐1 by inhibition of p‐JNK, NF‐κB and p‐Smad2/3 signalling.71 TGFβ‐1‐siRNA significantly improved the repair potential of MSCs against hepatic injury through TGF‐β1/Smad pathway, accompanied by down‐regulation of aminotransferases and reduced fibrosis area.72 The gene discussed is TGFB1; the disease is Hepatic fibrosis.