In Section 5 we conduct an MR study estimating the effects of four biomarkers (amyloid β [Aβ] 1–42, total tau protein [Ttau], phosphorylated tau protein [Ptau], and fluoro‐D‐glucose uptake [FDG_SUVR]) on Alzheimer’s disease (AD) risk using our methods. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.