The key findings were as follows: 1) day 0 no MI cardiac fibroblasts served as sentinel cells to actively maintain myocardial homeostasis; 2) cardiac fibroblasts underwent distinct transcriptomic changes at MI days 1, 3, and 7, with day 1 fibroblasts showing a pro-inflammatory signature, day 3 fibroblasts showing a proliferative, reparative, and pro-angiogenic profile, and day 7 fibroblasts showing homeostatic-like features and negatively regulating angiogenesis; and 3) the negative regulation of angiogenesis by day 7 fibroblasts occurred through Thbs1 signaling. Here, THBS1 is linked to myocardial infarction.