These findings from the ALSPAC cohort relating complement changes associated with PE, confirm and extend the findings from our previous smaller discovery proteomic study of age 12 protein biomarkers of psychotic disorders at age 18 [27], in which we also observed significant elevations of CFH and VTN and reductions in C4BPA and C4BPB. The gene discussed is C4BPB; the disease is psychotic disorder.