MAPT and Alzheimer disease: CSF tau measures were shown, in a related study, to exhibit differing patterns of association to [18F]AV1451: while p-tau was associated with tracer retention in temporoparietal areas, t-tau showed the strongest positive correlation with retention of [18F]AV1451 in prefrontal areas [186], regions known to exhibit tau pathology in more advanced stages of AD [17].