[18F]AV1451, tracers of the [18F]THK family, and [11C]PBB3 have, in single cases or groups of patients with a clinical diagnosis in the CBS/PSP spectrum, shown the regional pattern of tau pathology expected in these diseases with relatively good discrimination from healthy volunteers [19, 26, 35, 78–88]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.