CD4 and acute lymphoblastic leukemia: Similarly, the proportion of CD8+granzyme B+CD57+ T cells (11.5% vs. 24.0% of CD8+ T cells, q = 0.0001) as well as CD27+ T cells (7.9% vs. 21.5% of CD3+CD4+ T cells, q < 0.0001 and 7.7% vs. 34.6% of CD3+CD8+ T cells, q < 0.0001; Supplementary Figure S2) was decreased in ALL BM, suggesting suppressed cytolytic and co-stimulation ability, respectively.