The expression of PD1 (24.0 vs. 1.7% of CD4+ cells, q < 0.0001 and 21.2 vs. 2.0% of CD8 cells, q < 0.0001) and CTLA4 (9.4 vs. 0.9% of CD4+ cells, q < 0.0001 and 6.6 vs. 1.2% of CD8+ cells, q < 0.0001) was pronounced in ALL BM. Here, CD8A is linked to acute lymphoblastic leukemia.