CD4 and acute lymphoblastic leukemia: However, the expression of LAG3 (7.7 vs. 17.3% of CD4+ cells, q < 0.0001 and 4.8 vs. 19.3% of CD8+ cells, q < 0.0001) and TIM3 (0.0 vs. 0.8% of CD4+ cells, q < 0.0001 and 0.0 vs. 0.9% of CD8+ cells, q < 0.0001) were decreased in ALL compared to the control BM.