NG2+ blasts pre-exposed to BM-MSC for 30 min or 24 h displayed ∼20% or ∼40% increased resistance to VxL, respectively, indicating a BM stroma-mediated chemoprotection of MLLr-B-ALL blasts to induction therapy (Fig. 3b). Here, CSPG4 is linked to acute lymphoblastic leukemia.