If the presence of SM can be proven in KIT D816mut/CBFneg AML by bone marrow histology and elevated serum tryptase, KIT inhibitors (e.g., midostaurin, potentially avapritinib [BLU-285, Blueprint Medicines, Cambridge, MA, USA]) in combination with intensive chemotherapy and allogeneic SCT may help to improve the poor prognosis of this distinct AML subtype [50, 51]. Here, KIT is linked to acute myeloid leukemia.