In addition to the aforementioned similarities regarding the molecular genetic characteristics (KIT D816V VAF, additional somatic mutations, and aberrant karyotype), the poor median OS of 26 months in 17 KIT D816mut/CBFneg AML patients from the two independent AML databases adds further evidence that KIT D816mut/CBFneg AML may in fact represent SM-AML in the vast majority, if not all patients. Here, KIT is linked to acute myeloid leukemia.