We report multifaceted impairment in object processing, with interesting strain and sex differences in object identity memory (OR), spatial memory (object location; OL), and multisensory perceptual integration (multisensory object oddity; MSO) that correspond with pathological changes in Aβ42, phosphorylated tau (P-tau) and other proteins associated with AD pathology. The gene discussed is MAPT; the disease is Alzheimer disease.