Next, we re-expressed the MCL1L cDNA, which is resistant to E7107-induced splicing modulation, in two MCL1-dependent NSCLC cell lines by an inducible system, in order to evaluate whether it could rescue the MCL1-dependent cells from the cytotoxic effect of E7107 (Fig. 5d). The gene discussed is MCL1; the disease is non-small cell lung carcinoma.