We next tested E7107 in NSCLC cells, confirming that MCL1 gene is highly sensitive to E7107-induced splicing modulation, which led to downregulation of the pro-survival full-length (MCL1L) and induction of intron retention and a truncated short-form MCL1 (Fig. 5a). Here, MCL1 is linked to non-small cell lung carcinoma.