In contrast, in the TGF-β-low MC38-AS tumor model, similar to the B16-SIY model we found a synergistic antitumor effect of combination of anti-CD73/anti-4-1BB therapy (Supplementary Fig. 8A) accompanied by the enhanced accumulation of intratumoral CD8+ T cells producing IFN-γ (Supplementary Fig. 8B, C). This evidence concerns the gene IFNG and neoplasm.