Both overexpression of LIN28B and knockout (KO) of let-7 miRNAs results in an upregulation of the Igf2/H19 locus that has previously been associated with the persistence of metanephric blastema in both Wilms tumor and persistent nephrogenic rests persistence of a nephrogenic mesenchyme32. The gene discussed is IGF2; the disease is Nephroblastoma.