The pro-differentiation effect of RBM25 was also supported by analysis of murine Lp30 AML samples in vivo, where we observed a significant increase in the c-Kit (hematopoietic stem- and progenitor marker) to Mac1 (myeloid differentiation marker) ratio in engrafted BM Lp30 cells expressing low levels of Rbm25 (Supplementary Fig. 4c). Here, ITGAM is linked to acute myeloid leukemia.