SOD1 and amyotrophic lateral sclerosis: SOD1, the first known ALS locus (Rosen et al., 1993), has been implicated in sporadic as well as familial cases and was our first choice for validation of the S2R+ based screen in Drosophila. We previously identified Sod1 as a genetic interactor of VAP in a fly-based reverse genetics screen (Deivasigamani et al., 2014).