The infected mice exhibited increased mRNA (NLRP3: F(3,20) = 104.6, Caspase I: F(3,20) = 91.18, IL-1β: F(3,20) = 132.9, α-SMA: F(3,20) = 167.4, Collagen I: F(3,20) = 245.4; all P < 0.0001) and protein (NLRP3: F(3,20) = 51.83, Caspase I: F(3,20) = 143.9, IL-1β: F(3,20) = 203.5, α-SMA: F(3,20) = 81.15, Collagen I: F(3,20) = 19.12; all P < 0.0001) expressions of NLRP3 inflammasome (Fig. 2b, c) and liver fibrosis markers (α-SMA and Collagen I) (Fig. 2d). This evidence concerns the gene IL1B and Hepatic fibrosis.