To further study the relationship between NLRP3 inflammasome and liver fibrosis during S. japonicum infection, we infected BALB/c mice in a similar way, but infected mice then received i.p. injections of MCC950 or vehicle, on the day of infection (M0 group) or at day 22 post-infection (M4 group) (experimental design summarized in Fig. 2a). This evidence concerns the gene NLRP3 and infection.