To better demonstrate which kind of cells originated from NLRP3 inflammasome implicated in hepatic fibrosis (particularly in KCs or HSCs in mice infected with S. japonicum), we examined the co-localization of NLRP3 with the KCs marker F4/80 or with the HSCs marker α-SMA in liver tissues. The gene discussed is ACTA1; the disease is Hepatic fibrosis.