In addition, subjects with WS had higher rates of positive AGA IgA and IgG compared to IBS subjects without WS (P = .0001 and P = .0001, respectively), and subjects with WS alone had a higher frequency of HLA DQ2 or DQ8 positivity compared to subjects with WS-MFH (P = .0001). The gene discussed is CD79A; the disease is irritable bowel syndrome.