Importantly, we show that glycolysis in inflammatory M(LPS + IFNγ) microglia also relays on GLUT1-mediated glucose uptake, and blocking GLUT1 re-programmed proinflammatory microglia from glycolysis to OXPHOX, suppressed microglial activation and reduced light-induced retinal degeneration. Here, SLC2A1 is linked to retinal degeneration.