The observed difference in hazard ratios among myocardial infarction, stroke and amputation suggest that a primary anti-atherosclerotic effect of the SGLT2 inhibitors is unlikely since such an effect would have been expected to reduce myocardial infarction and stroke similarly, as is the case with cholesterol lowering [3] and antihypertensive therapy [4]. This evidence concerns the gene SLC5A2 and Stroke.