Interestingly, a number of genes encoding CTAs that are potentially useful for developing cancer vaccines were in the list of 63 CTA genes with higher expression levels in the higher-TMB subtype, such as MAGEA (MAGEA-1, 2, 3, 4, 6, 8, 9B, 10, 11, 12), NY-ESO-1, and PRAME. The gene discussed is PRAME; the disease is cancer.