The 12 genes included LAG3, CD80, TNFSF9, IDO1, CD70, KIR3DL1, CTLA4, PD-1, PD-L1, PD-L2, TIGIT, and TNFRSF9. Notably, LAG3 had higher expression levels in the higher-TMB subtype of 10 cancer types versus 2 cancer types of which LAG3 showed higher expression levels in the lower-TMB subtype. This evidence concerns the gene CTLA4 and cancer.