PRDM16 and migraine disorder: Another, rather unexpected, hypothesis that emerges is that metal ion homeostasis might contribute to migraine susceptibility, as 11 genes (PRDM16, TGFBR2, REST, FHL5, NRP1, MMPED2, LRP1, ZCCHC14, RNF213, JAG1, SLC24A3) with such function are among the 37 genes.