Another, rather unexpected, hypothesis that emerges is that metal ion homeostasis might contribute to migraine susceptibility, as 11 genes (PRDM16, TGFBR2, REST, FHL5, NRP1, MMPED2, LRP1, ZCCHC14, RNF213, JAG1, SLC24A3) with such function are among the 37 genes. This evidence concerns the gene LRP1 and migraine disorder.