CXCL8 and acute myeloid leukemia: However, according to the current study, the AML cell population showing morphological alterations after 2–3 weeks of suspension culture had the highest absolute mediator levels of all samples (Mann-Whitney U-test; p ≤ 0.01): initial (week 1) high levels for CCL4, CXCL8, IL-1RA, HGF, MMP-1/9, and cystatin C; and persistent (week 1 and week 5) high levels for CCL2, CXCL5/10, IL-1β, G-CSF, and TNFα (Supplementary Table S4).