IL1B and acute myeloid leukemia: However, the observed cytokine differences among patients with and without long-term proliferation (Figure 2 and Figure 3) suggest that these two subsets show additional differences with regard to communication via the local cytokine network (i.e., IL-1/IL-1RA, HGF) with neighboring AML-supporting stromal cells in their common bone marrow microenvironment.