Furthermore, expression of four proteins is associated with tumor progression/high risk AML: DOT1L, mTOR, VIM and ZNF521 [26,27,28,29,30], whereas the expression of six proteins is associated with tumor suppression/low risk AML: AEBP2, CAST, CBFB, LSP1, MAP1S and probably PCBP1 [31,32,33,34,35]. The gene discussed is CBFB; the disease is acute myeloid leukemia.